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Metabolic syndrome is a cluster of conditions that often occur together such as obesity, high blood sugar, high blood pressure, and high cholesterol, which can lead to cardiovascular disease. The underlying cause of metabolic syndrome may be a resistance to insulin. Treatment for metabolic syndrome includes making lifestyle changes such as getting more exercise, losing weight, dietary changes, and stopping smoking. If lifestyle changes donít have the desired results, medications may be prescribed to treat different aspects of the syndrome.